Active Pharmaceutical Ingredient

Pemetrexed

Also known as: Alimta

CAS: 137281-23-3 Antifolate IP / BP / EP / USP GMP Certified Aurangabad, Maharashtra, India
Pemetrexed API — Mediocon Inc
Pemetrexed — Pharmaceutical Grade API

Product Overview

CAS No: 137281-23-3  |  MF: C₂₀H₂₁N₅O₆  |  MW: 427.41 g/mol

Pemetrexed is a pharmaceutical-grade active ingredient classified as an Antifolate Antineoplastic Agent. Mediocon Inc supplies high-purity Pemetrexed API conforming to IP / BP / EP / USP specifications, manufactured in our GMP-certified facility in Aurangabad, Maharashtra, India.

Pemetrexed disrupts folate-dependent metabolic processes essential for cell replication. It inhibits multiple enzymes including thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase, blocking DNA and RNA synthesis in rapidly dividing cancer cells.

Key Features

  • High-purity pharmaceutical grade API
  • IP/BP/EP/USP compliant
  • Full CoA and MSDS documentation
  • GMP certified manufacturing

Applications

  • Malignant pleural mesothelioma
  • Non-small cell lung cancer (NSCLC)
  • Combination with cisplatin for lung cancer
  • Maintenance therapy in NSCLC

Why Choose Mediocon

  • ISO 9001:2015 & GMP certified manufacturing
  • Consistent batch-to-batch quality with full CoA
  • Export-ready documentation: COO, MSDS, DMF
  • Flexible MOQ for both R&D and commercial scale
  • Dedicated QA support for regulatory filings

Product Specifications

Product NamePemetrexed
Also Known AsAlimta
CAS Number137281-23-3
Molecular FormulaC₂₀H₂₁N₅O₆
Molecular Weight427.41 g/mol
CategoryAntifolate — Antineoplastic Agent
AppearanceWhite to light yellow lyophilized powder
SolubilitySoluble in water at alkaline pH
GradeIP / BP / EP / USP

Analytical Specifications

ParameterSpecification
AssayNLT 98.0%
Loss on DryingNMT 0.5%
Heavy MetalsNMT 20 ppm
Residue on IgnitionNMT 0.1%
Microbial LimitsComplies with pharmacopoeia
IdentificationIR, HPLC Compliant
Packing25 kg HDPE drums / as per requirement
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