Active Pharmaceutical Ingredient

Methotrexate — CAS 59-05-2

Also known as: Rheumatrex; Trexall; Otrexup; MTX

GMP Certified I.P. / B.P. / E.P. / U.S.P. Antimetabolite / Antifolate / DMARD Aurangabad, India
Methotrexate API Supplier Manufacturer Aurangabad Maharashtra India — Mediocon Inc
Methotrexate I.P. / B.P. / E.P. / U.S.P.  |  GMP Certified  |  Mediocon Inc, Maharashtra, India
CAS No: 59-05-2

Product Overview

Methotrexate is a high-purity Active Pharmaceutical Ingredient (API) classified as a Antimetabolite / Antifolate / DMARD. Manufactured by Mediocon Inc in Aurangabad, Maharashtra, India at a GMP-certified facility, it is supplied in bulk for pharmaceutical formulations worldwide. CAS No: 59-05-2.

Therapeutic Applications
  • Rheumatoid arthritis (DMARD therapy)
  • Acute lymphoblastic leukemia (ALL)
  • Psoriasis and psoriatic arthritis
  • Non-Hodgkin's lymphoma treatment
  • Ectopic pregnancy management

Technical Specifications

ParameterSpecification
CAS Number59-05-2
Molecular FormulaC₂₀H₂₂N₈O₅
Molecular Weight454.44 g/mol
GradeI.P. / B.P. / E.P. / U.S.P.
CategoryAntimetabolite / Antifolate / DMARD
AppearanceWhite to off-white crystalline powder
SolubilitySlightly soluble in water; soluble in methanol
AssayNLT 98.0%
Loss on DryingNMT 0.5%
Heavy MetalsNMT 20 ppm
Residue on IgnitionNMT 0.1%
Microbial LimitsComplies with pharmacopoeia
IdentificationIR, HPLC Compliant
Batch NoMTR/24032026
Mfg DateMAR 2026
Exp DateFEB 2031
Packing25 kg HDPE drums / as per requirement

Quality & Compliance

  • GMP Certified manufacturing facility in Aurangabad, Maharashtra, India
  • Full pharmacopoeial compliance: I.P. / B.P. / E.P. / U.S.P. standards
  • Complete documentation: Certificate of Analysis (CoA), MSDS, Certificate of Origin
  • Stringent in-process quality control at every manufacturing stage
  • HPLC purity testing and spectroscopic identification (IR, NMR)
  • Cold-chain and controlled-environment storage facilities available
  • Exported to 40+ countries with full regulatory support
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