Active Pharmaceutical Ingredient

Tolcapone

Also known as: Tasmar; Ro 40-7592

CAS: 134308-13-7COMT Inhibitor / Anti-Parkinson APIIP / BP / EP / USPGMP CertifiedAurangabad, Maharashtra, India
Tolcapone API — Mediocon Inc
Tolcapone — Pharmaceutical Grade API | Mediocon Inc, Aurangabad, Maharashtra, India

Product Overview

CAS No: 134308-13-7  |  MF: C₁₄H₁₁NO₅  |  MW: 273.24 g/mol

Tolcapone is a high-purity Active Pharmaceutical Ingredient supplied by Mediocon Inc conforming to IP / BP / EP / USP specifications. Manufactured at our GMP-certified facility in Aurangabad, Maharashtra, India.

Tolcapone is a selective, reversible catechol-O-methyltransferase (COMT) inhibitor used as adjunctive therapy to levodopa/carbidopa in Parkinson's disease. It prolongs levodopa action by inhibiting peripheral and central dopamine metabolism.

Key Features

  • High-purity pharmaceutical grade API
  • IP / BP / EP / USP compliant
  • Full CoA and MSDS documentation
  • GMP certified manufacturing facility

Applications

  • Parkinson's disease adjunctive therapy
  • COMT inhibition
  • Levodopa plasma half-life extension
  • End-of-dose fluctuation control

Why Choose Mediocon

  • ISO 9001:2015 & GMP certified manufacturing
  • Consistent batch-to-batch quality with full CoA
  • Export-ready documentation: COO, MSDS, DMF
  • Flexible MOQ for both R&D and commercial scale
  • Dedicated QA support for regulatory filings

Product Specifications

Product NameTolcapone
Also Known AsTasmar; Ro 40-7592
CAS Number134308-13-7
Molecular FormulaC₁₄H₁₁NO₅
Molecular Weight273.24 g/mol
CategoryCOMT Inhibitor / Anti-Parkinson Agent / Active Pharmaceutical Ingredient
AppearanceBright yellow crystalline powder
SolubilitySlightly soluble in water; soluble in ethanol and DMSO
GradeIP / BP / EP / USP

Analytical Specifications

ParameterSpecification
AssayNLT 98.0%
Loss on DryingNMT 0.5%
Heavy MetalsNMT 20 ppm
Residue on IgnitionNMT 0.1%
Microbial LimitsComplies with pharmacopoeia
IdentificationIR, HPLC Compliant
Batch No.TLC/24032026
Mfg DateMAR 2026
Exp DateFEB 2031
Packing25 kg HDPE drums / as per requirement
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