Active Pharmaceutical Ingredient

Trimetrexate

Also known as: Neutrexin; TMX

CAS: 52128-35-5Antifolate APIIP / BP / EP / USPGMP CertifiedAurangabad, Maharashtra, India
Trimetrexate API — Mediocon Inc
Trimetrexate — Pharmaceutical Grade API | Mediocon Inc, Aurangabad, Maharashtra, India

Product Overview

CAS No: 52128-35-5  |  MF: C₁₉H₂₃N₅O₃  |  MW: 369.42 g/mol

Trimetrexate is a high-purity Active Pharmaceutical Ingredient supplied by Mediocon Inc conforming to IP / BP / EP / USP specifications. Manufactured at our GMP-certified facility in Aurangabad, Maharashtra, India.

Trimetrexate is a lipid-soluble antifolate agent that inhibits dihydrofolate reductase (DHFR). It has been used as an alternative treatment for Pneumocystis carinii pneumonia (PCP) in immunocompromised patients, including those with HIV/AIDS, who cannot tolerate standard therapies.

Key Features

  • High-purity pharmaceutical grade API
  • IP / BP / EP / USP compliant
  • Full CoA and MSDS documentation
  • GMP certified manufacturing facility

Applications

  • Pneumocystis carinii pneumonia (PCP) treatment
  • HIV/AIDS opportunistic infection management
  • Antineoplastic research applications
  • Antifolate mechanism studies

Why Choose Mediocon

  • ISO 9001:2015 & GMP certified manufacturing
  • Consistent batch-to-batch quality with full CoA
  • Export-ready documentation: COO, MSDS, DMF
  • Flexible MOQ for both R&D and commercial scale
  • Dedicated QA support for regulatory filings

Product Specifications

Product NameTrimetrexate
Also Known AsNeutrexin; TMX
CAS Number52128-35-5
Molecular FormulaC₁₉H₂₃N₅O₃
Molecular Weight369.42 g/mol
CategoryAntifolate / Antineoplastic Agent
AppearanceWhite to off-white crystalline powder
SolubilitySoluble in water and methanol; slightly soluble in ethanol
GradeIP / BP / EP / USP

Analytical Specifications

ParameterSpecification
AssayNLT 98.0%
Loss on DryingNMT 0.5%
Heavy MetalsNMT 20 ppm
Residue on IgnitionNMT 0.1%
Microbial LimitsComplies with pharmacopoeia
IdentificationIR, HPLC Compliant
Batch No.TMX/24032026
Mfg DateMAR 2026
Exp DateFEB 2031
Packing25 kg HDPE drums / as per requirement
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